Crystal Palace will travel to the South coast for Wednesday's Premier League encounter against basement side Southampton.
The Eagles will be in a celebratory mood after cruising to a 3-0 victory in Saturday's FA Cup quarter-final against Fulham, setting up a last-four clash with Aston Villa as they continue to dream about winning the competition for the first time in their history.
Oliver Glasner's side will now turn their focus back to league action, with the Eagles sitting in 12th spot after collecting 39 points from their 28 top-flight matches.
Meanwhile, the writing is on the wall for Southampton, who are languishing at the foot of the table with 17 points separating them from safety, having won just two of their 29 league games this season (D3, L24).
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
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Head-to-head record
Previous meetings: 118
Southampton wins: 49
Draws: 25
Crystal Palace wins: 44
Southampton have the slight edge over Palace, having won 49 of their 118 competitive meetings, compared to 44 wins for the Eagles.
The two teams first met 119 years ago in September 1906 when they played out a 1-1 draw in a Southern League fixture.
That result proved to be the first of four winless games for the Saints, before they finally picked up a 3-2 victory in September 1908.
In the modern era, two clubs have faced off in 29 Premier League matches, producing 14 Southampton wins, seven draws and eight wins for Palace.
Having scored four top-flight goals in this fixture, Palace's Eberechi Eze is joint-top scorer in Premier League head-to-head meetings, along with Danny Ings, Christian Benteke and Wilfried Zaha.
Palace have enjoyed success in recent times, having avoided defeat in their last five of their top-flight matches against the South-coast side.
They started that impressive run with a 2-2 draw in December 2021, before they went on to record three consecutive league wins, including a 2-1 home victory in their most recent meeting in December 2024.
As a result, Southampton have not beaten Palace in the Premier League since they claimed a 3-1 victory at St Mary's in May 2021.
However, they did enjoy a successful trip to Selhurst Park in January 2023 when they edged out Palace via a 2-1 scoreline in an FA Cup third-round clash.
That result represented the only win they have picked up in their last five competitive away meetings with the Eagles (D1, L3).
Palace have also been strong in their recent visits to St Mary's, having won three, drawn two and lost one of their previous six competitive away matches.
Previous meetings
Dec 29, 2024: Crystal Palace 2-1 Southampton (Premier League)
Apr 15, 2023: Southampton 0-2 Crystal Palace (Premier League)
Jan 07, 2023: Crystal Palace 1-2 Southampton (FA Cup Third Round)
Oct 29, 2022: Crystal Palace 1-0 Southampton (Premier League)
Apr 30, 2022: Southampton 1-2 Crystal Palace (Premier League)
Dec 15, 2021: Crystal Palace 2-2 Southampton (Premier League)
May 11, 2021: Southampton 3-1 Crystal Palace (Premier League)
Sep 12, 2020: Crystal Palace 1-0 Southampton (Premier League)
Jan 21, 2020: Crystal Palace 0-2 Southampton (Premier League)
Dec 28, 2019: Southampton 1-1 Crystal Palace (Premier League)
Jan 30, 2019: Southampton 1-1 Crystal Palace (Premier League)
Sep 01, 2018: Crystal Palace 0-2 Southampton (Premier League)
Jan 02, 2018: Southampton 1-2 Crystal Palace (Premier League)
Sep 16, 2017: Crystal Palace 0-1 Southampton (Premier League)
Apr 05, 2017: Southampton 3-1 Crystal Palace (Premier League)
Dec 03, 2016: Crystal Palace 3-0 Southampton (Premier League)
Sep 21, 2016: Southampton 2-0 Crystal Palace (EFL Cup Round Three)
May 15, 2016: Southampton 4-1 Crystal Palace (Premier League)
Jan 09, 2016: Southampton 1-2 Crystal Palace (FA Cup Third Round)
Dec 12, 2015: Crystal Palace 1-0 Southampton (Premier League)
Last 10 Premier League meetings
Dec 29, 2024: Crystal Palace 2-1 Southampton (Premier League)
Apr 15, 2023: Southampton 0-2 Crystal Palace (Premier League)
Oct 29, 2022: Crystal Palace 1-0 Southampton (Premier League)
Apr 30, 2022: Southampton 1-2 Crystal Palace (Premier League)
Dec 15, 2021: Crystal Palace 2-2 Southampton (Premier League)
May 11, 2021: Southampton 3-1 Crystal Palace (Premier League)
Sep 12, 2020: Crystal Palace 1-0 Southampton (Premier League)
Jan 21, 2020: Crystal Palace 0-2 Southampton (Premier League)
Dec 28, 2019: Southampton 1-1 Crystal Palace (Premier League)
Jan 30, 2019: Southampton 1-1 Crystal Palace (Premier League)
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