Crystal Palace manager Oliver Glasner will be forced to make at least one change for Wednesday's Premier League clash with Southampton at St Mary's.

The Eagles returned from the international break with a successful outing in Saturday's FA Cup quarter-final clash against Fulham.

Eberechi Eze, Ismaila Sarr and Eddie Nketiah all got on the scoresheet to guide Palace to a commanding 3-0 victory, setting up a semi-final clash against Aston Villa.

Chris Richards played the full duration of the FA Cup win, but Glasner has revealed he will miss the midweek fixture due to a calf problem.

As a result, Nathaniel Clyne could be given the chance to feature in a back three alongside Maxence Lacroix and Marc Guehi.

Daniel Munoz will feature on the right side of a midfield four, while Tyrick Mitchell will continue to operate as the left wing-back.

Adam Wharton is set to make a third successive Premier League start, with the 21-year-old expected to resume his central midfield partnership with Jefferson Lerma.

Eze and Sarr will feature in the two number 10 roles in the 3-4-2-1 formation, offering support to striker Jean-Philippe Mateta, who played 70 minutes at the weekend in his first appearance since he sustained a nasty ear injury in the FA Cup fifth-round tie against Millwall.

Will Hughes missed the cup success due to illness, and while he could recover by Wednesday's fixture, he will have to serve the second game of a two-match ban for yellow card accumulation.

The Eagles are also without the services of Joel Ward, Chadi Riad and Cheick Doucoure, who are all sidelined with injury issues.

Crystal Palace possible starting lineup: Henderson; Clyne, Lacroix, Guehi; Munoz, Wharton, Lerma, Mitchell; Sarr, Eze; Mateta

>Click here to see how Southampton could line up for this fixture