Rasmus Hojlund, Antony, Sofyan Amrabat and Aaron Wan-Bissaka have come into the Manchester United side for Wednesday's Champions League clash with Galatasaray in Istanbul.
There had been fears that the fixture could have to be postponed due to heavy rainfall in Istanbul, but UEFA have confirmed that the match will go ahead as planned.
Red Devils head coach Erik ten Hag has made four changes to the side that started the 3-0 win over Everton in the Premier League on Sunday afternoon.
Hojlund and Antony were both absent against the Toffees due to injuries, but the pair are back in the XI for this match, with Anthony Martial dropping to the bench and Marcus Rashford suspended.
Amrabat comes in for Kobbie Mainoo, who was outstanding on his full Premier League debut at Goodison Park, while Wan-Bissaka replaces Diogo Dalot, with the Portugal international on the bench.
Raphael Varane is again on the bench, with Harry Maguire and Victor Lindelof featuring in the middle of the defence in the absence of Jonny Evans.
As for Galatasaray, Wilfried Zaha will line up against his former club in a wide area, while there are also familiar faces in the shape of Tanguy Ndombele, Lucas Torreira and Hakim Ziyech.
Dries Mertens is also given the nod in a forward position for the Turkish giants, while Mauro Icardi will lead the line, with the forward looking to add to the 16 goals that he has managed in all competitions this term.
Davinson Sanchez, though, is unavailable for the home side here due to injury.
Man United sit at the bottom of Group A, one point behind third-placed Galatasaray, while second-placed Copenhagen are level with the Turkish side on four points.
Galatasaray: Muslera; Boey, Bardakci, Ayhan, Angelino; Ndombele, Torreira; Ziyech, Mertens, Zaha; Icardi
Subs: Gunay, Akturkoglu, Demirbay, Tete, Nelsson, Sergio, Baris, Kazimcan, Bakambu
Manchester United: Onana; Wan-Bissaka, Maguire, Lindelof, Shaw; Amrabat, McTominay; Antony, Fernandes, Garnacho; Hojlund
Subs: Bayindir, Heaton, Dalot, Varane, Reguilon, Gore, Hannibal, Mainoo, Pellistri, Hugill, Martial
