With a maximum of 10 points required from their final six La Liga outings to secure the league title, Carlo Ancelotti should deploy a full-strength squad for his side's trip to Osasuna on Wednesday.
Los Blancos have several issues to contend with, as left-backs Ferland Mendy and Marcelo are both expected to miss out through adductor issues, while winger Eden Hazard remains sidelined alongside Luka Jovic.
In the absence of their two main left-sided defenders, Dani Carvajal could again operate on that side, with Ancelotti preferring to keep David Alaba in the middle of the back four alongside Eder Militao, while Lucas Vazquez should again play on the right.
Further forward, key midfielder Casemiro will return to contention following a suspension, putting young Frenchman Eduardo Camavinga's place at risk with Toni Kroos and Luka Modric both expected to start, while Federico Valverde could also drop out of the front three.
Brazilian winger Rodrygo has scored off the bench in each of their last two matches, crucially taking their Champions League quarter-final tie with Chelsea to extra time and equalising in their eventual win over Sevilla last time out, and he will be vying for a spot on the right wing as a result.
He could feature on the opposite flank to compatriot Vinicius Junior, who has netted 16 goals and provided 17 assists in 40 appearances across La Liga and Champions League action this term.
Karim Benzema will continue to lead the line, having enjoyed his most productive season for the club this year, scoring 25 goals and contributing 11 assists in the Spanish top flight and finding the net 12 times in just nine Champions League appearances.
Real Madrid possible starting lineup: Courtois; Vazquez, Alaba, Militao, Carvajal; Kroos, Casemiro, Modric; Rodrygo, Benzema, Vinicius
