Manchester United boss Erik ten Hag is likely to make some changes to his starting XI after suffering a 6-3 defeat to their city rivals Manchester City last weekend.
The Red Devils saw a streak of four successive league wins come to a crashing end at the Etihad Stadium, with only a late brace from substitute Anthony Martial making the scoreline appear less embarrassing for his side.
The France forward scored from the bench again to help Man Utd turn the game around against Omonia in the Europa League on Thursday, and he appears to be in line for his first start of the season having impressed during pre-season before suffering a serious tendon injury.
Marcus Rashford, who bagged a brace despite only coming on at half-time of his side's 3-2 win in Cyprus in midweek, could shift to the left flank in order to accommodate Martial through the middle, with Jadon Sancho likely to make way after being hooked at half-time.
Ten Hag branded his side as being "not very good" in his post-match press conference on Thursday, suggesting further changes are likely to be made, with Luke Shaw potentially replacing Tyrell Malacia at left-back.
The Dutchman has been subbed at half-time in each of Man Utd's two matches in the past week, with Shaw looking like a man with a point to prove - and a place in England's World Cup starting XI to win - on both occasions.
Raphael Varane was taken off before half-time against Man City due to an ankle injury, but the France defender may win his race to recover in time for Sunday's trip to Merseyside.
Harry Maguire, Aaron Wan-Bissaka and Donny van de Beek have all been ruled out of taking part due to injury, though, while Mason Greenwood remains persona non grata for off-field reasons.
Manchester United possible starting lineup: De Gea; Dalot, Varane, Martinez, Shaw; McTominay, Eriksen; Antony, Fernandes, Rashford; Martial
