Manchester United manager Erik ten Hag will have to cope without the suspended Casemiro for Sunday's Premier League clash with table-toppers Arsenal at the Emirates Stadium.
The Brazilian midfielder was booked for the fifth time this season for a cynical lunge on Wilfried Zaha in Wednesday's 1-1 draw with Crystal Palace, and he will take his place on the naughty step for this one.
Ten Hag is also guaranteed to be without the injured Axel Tuanzebe and Donny van de Beek, while Diogo Dalot and Anthony Martial's problems will both need assessing.
Jack Butland will return after being ineligible to face his parent club at Selhurst Park, but the Palace loanee will take up a spot on the bench as David de Gea continues in goal.
Lisandro Martinez returned to the backline on Wednesday and should hold his spot alongside Raphael Varane, allowing Luke Shaw to take up his regular position on the left-hand side.
Should Dalot miss out, Aaron Wan-Bissaka will have the unenviable task of trying to keep Gabriel Martinelli quiet, while Fred is the most likely candidate to deputise for Casemiro alongside Christian Eriksen.
Jadon Sancho has now returned to Man United training, but Antony, Bruno Fernandes and Marcus Rashford - who has four goals and four assists from 10 Premier League starts against Arsenal - are all set to hold their places.
Burnley loanee Wout Weghorst is also in line for back-to-back starts as Ten Hag urges caution over Martial, and the Dutch coach was pleased with the striker's debut in the draw with Palace.
Manchester United possible starting lineup: De Gea; Wan-Bissaka, Varane, Martinez, Shaw; Eriksen, Fred; Antony, Fernandes, Rashford; Weghorst
> Click here to see how Arsenal could line up for this match
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