Manchester United will be missing at least three players for Saturday's Premier League clash with Watford at Vicarage Road.
Raphael Varane is still unavailable due to a hamstring problem, while Paul Pogba picked up a thigh issue with France over the recent international break, although the midfielder would have missed out against the Hornets regardless through suspension.
Edinson Cavani is also out as he battles a troublesome tendon issue, but the 20-time English champions are expected to have Scott McTominay and Luke Shaw available for selection.
McTominay was forced to pull out of the Scotland squad due to a throat infection but should be cleared to feature, while Shaw is likely to be passed fit despite not joining up with the England squad for their World Cup qualifiers as he followed concussion protocols.
Donny van de Beek, Jesse Lingard and Jadon Sancho will be among those hoping to be given an opportunity to impress against the Hornets.
However, it seems likely that head coach Ole Gunnar Solskjaer will select Mason Greenwood and Marcus Rashford in support of Cristiano Ronaldo, ditching the 3-5-2 formation in the process.
Fred is likely to line up alongside McTominay in the middle of the park, while Harry Maguire will again captain the team despite being heavily criticised for his club performances in recent weeks.
Manchester United possible starting lineup: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Greenwood, Fernandes, Rashford; Ronaldo
