Barcelona manager Luis Enrique has handed debuts to summer signings Jasper Cillessen and Paco Alcacer for the visit of Alaves to Camp Nou.
Cillessen, a £13m capture from Dutch giants Ajax a fortnight ago, comes in between the sticks in place of Claudio Bravo, who departed for Manchester City.
There is a place up top for Alcacer, meanwhile, as he joins a makeshift front trio made up of returning Olympic hero Neymar and a rejuvenated Arda Turan.
Luis Suarez and Lionel Messi are both left on the bench following their international exploits with Uruguay and Argentina respectively, with the latter picking up a knock that has restricted his training in the build-up to tonight's match.
In terms of the visitors, Deyverson will again lead the line for Mauricio Pellegrino's men in a side that shows no changes from the goalless draw with Sporting Gijon a fortnight ago.
Barcelona: Cillessen; Vidal, Mascherano, Mathieu, Digne; Rakitic, Busquets, Denis; Arda Turan, Alcacer, Neymar
Subs: Masip, Alba, Umtiti, Iniesta, Rafinha, Messi, Suarez
Alaves: Pacheco; Laguardia, Alexis, Hernandez, Garcia; Torres, Femenia, Llorente; Mendez, Deyverson, Ibai
Subs: Camarasa, Santos, Ortola, Espinoza, Manu Garcia, Vigaray, Toquero
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