The champions of Spain, France and Netherlands are all in action on Friday night, headlined by Atletico Madrid's meeting with Cadiz.
Lille face Saint-Etienne in Ligue 1 and Ajax visit Cambuur in the Eredivisie, while there is also a Championship clash between West Bromwich Albion and Huddersfield Town.
Below is Sports Mole's selection of predictions and previews for today's and tomorrow's fixtures.
