Spain boss Julen Lopetegui has handed an international debut to defender Alvaro Odriozola for the World Cup qualifier with Albania.
The right-back has previously represented his nation's Under-21 side, but the 21-year-old's form in La Liga has led to an introduction to the starting lineup for the senior side.
Spain are missing Alvaro Morata in attack, so Valencia frontman Rodrigo is given a chance to partner Isco and David Silva in the final third.
Barcelona's Gerard Pique and Real Madrid's Sergio Ramos feature in the centre of defence, despite reports suggesting that there had been a breakdown in their relationship.
As for Albania, Taulant Xhaka - the brother of Arsenal midfielder Granit - and Lazio defender Elseid Hysaj take their place in the team.
Spain: De Gea; Odriozola, Ramos, Pique, Alba; Saul, Koke, Thiago; Silva, Rodrigo, Isco
Albania: Berisha; Hysaj, Ajeti, Veseli, Balliu; Memushaj, Xhaka, Kace; Grezda, Llullaku, Memolla
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