Real Madrid travelled to the Camp Nou on Saturday knowing that three points against Barcelona would move them level on points with the Catalan outfit at the top of the table.
The home side opened the scoring after 19 minutes when Neymar, who was taking part in his first Clasico, slotted a low effort into the bottom corner.
Real Madrid had most of the opportunities in the second period, but a strike from Alexis Sanchez after 78 minutes secured all the points for Barcelona, despite Jese Rodriguez registering late on for the away side.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
BARCELONA: Valdes; Alves, Pique, Mascherano, Adriano; Busquets, Fabregas, Xavi; Iniesta, Messi, Neymar
REAL MADRID: Lopez; Carvajal, Ramos, Varane, Marcelo; Khedira, Pepe, Modric; Ronaldo, Bale, Di Maria