Manchester United will again be missing Edinson Cavani for Sunday's Premier League clash with Leeds United, as the striker is yet to recover from a groin problem and also now has a separate stomach issue.
Cavani's absence means that Cristiano Ronaldo is set to lead the line once again despite this match coming just three days before a trip to Atletico Madrid in the Champions League.
Mason Greenwood (club suspension) and Tom Heaton (groin) are also out, but Nemanja Matic and Eric Bailly could recover from shin and ankle problems respectively to make the squad.
Raphael Varane has also recovered from the illness that forced him to pull out of the starting side against Brighton & Hove Albion in the Premier League on Tuesday night.
Interim head coach Ralf Rangnick could make three changes from the side that started the 2-0 success over Brighton, with Varane likely to take Victor Lindelof's spot at the back.
Paul Pogba could also return to midfield in place of Fred, while Marcus Rashford is pushing to replace Anthony Elanga in the starting side at Elland Road.
As mentioned, Man United head to Atletico next week for the first leg of their last-16 clash in the Champions League, but the importance of this match means that Rangnick cannot afford to shuffle his pack.
Alex Telles is an option, though, should Luke Shaw be rested ahead of the trip to Wanda Metropolitano.
Manchester United possible starting lineup: De Gea; Dalot, Varane, Maguire, Shaw; Fernandes, McTominay, Pogba; Rashford, Ronaldo, Sancho
