Watford strikers Troy Deeney and Andre Gray both start for the Hornets against Brighton & Hove Albion.
Meanwhile, Abdoulaye Doucoure has recovered from appendicitis that kept him out of pre-season as Javi Gracia's men begin at Vicarage Road.
Ben Foster makes his debut in goal for Watford, while Jose Holebas, Craig Cathcart and Daryl Janmaat feature in the defence.
Will Hughes and Etienne Capoue start in midfield, before the 4-4-2 formation is completed by the presence of attacking duo Gray and Deeney.
Brighton boss Chris Hughton continues with Australian international Matt Ryan between the sticks, with Lewis Dunk and new signing Bernardo featuring in defence.
Anthony Knockaert, Dale Stephens and Pascal Gross are part of a five-man midfield that will provide support up top to English forward Glenn Murray, who has shook off back and neck knocks to earn a starting place.
Watford: Foster; Holebas, Kabasele, Cathcart, Janmaat; Pereyra, Doucoure, Capoue, Hughes; Deeney, Gray
Subs: Gomes, Prodl, Mariappa, Femenia, Masina, Sema, Success
Brighton & Hove Albion: Ryan; Bruno, Dunk, Duffy, Bernardo; Knockaert, Stephens, Propper, March, Gross, Murray
Subs: Button, Bong, Balogun, Jahanbakhsh, Bissouma, Kayal, Locadia
