Tottenham Hotspur head coach Antonio Conte is expected to select a strong side for Tuesday's FA Cup fifth-round contest with Middlesbrough at the Riverside Stadium.
Rodrigo Bentancur will miss out with an ankle problem, while Oliver Skipp and Japhet Tanganga will not be involved due to their recent injury problems.
Lucas Moura missed out on Saturday's match against Leeds United due to a knock that he picked up in training, and the Brazilian has also been ruled out of this game.
Harry Kane, Son Heung-min and Dejan Kulusevski are expected to start as the front three on Tuesday, with Conte unlikely to take any risks when it comes to team selection.
That said, there are likely to be changes from the side that started against Leeds, with Emerson Royal and Sergio Reguilon potentially coming into the side in the wing-back positions, while Davinson Sanchez could replace Cristian Romero at the back.
Joe Rodon and Steven Bergwijn will also be among those hoping to earn some valuable minutes, but there are unlikely to be any changes in midfield due to a lack of options.
Dane Scarlett was a late substitute against Leeds on Saturday, and the 17-year-old could again be used off the bench here depending on how the match develops.
Tottenham Hotspur possible starting lineup: Lloris; Sanchez, Dier, Davies; Emerson, Winks, Hojbjerg, Reguilon; Kulusevski, Kane, Son
