Head coach Thomas Tuchel has acknowledged that Chelsea's two experiences of playing against Real Madrid over the past year "cannot be more different".
At the semi-final stage last year, Chelsea collected a 1-1 draw from the first leg, which was played at Estadio Alfredo Di Stefano due to the Santiago Bernabeu undergoing renovation work.
However, already trailing 3-1 on aggregate in this year's last-eight tie, Chelsea will travel to Los Blancos' famous home, something which Tuchel describes as one of the sport's "biggest challenges".
Speaking to reporters at a press conference, Tuchel said: "It cannot be more different. It is one of the biggest challenges to perform as an away team in Bernabeu. It is even more difficult if you have to earn a certain result, if you need to win with a minimum of two goals, or maybe even a three-goal difference, it makes it almost impossible.
"It will be very difficult but it is still worth trying. It is still a stage where you can also over-perform. We need to over-perform. It's a big experience to learn from and maybe experience and over-perform."
Chelsea travel to Spain without the services of Romelu Lukaku, but Cesar Azpilicueta is due to return to the squad after missing Saturday's meeting with Southampton.
